Vignette d'image

Reyes Avila, Sarai

Nom
Reyes Avila, Sarai
Affiliation principale
Fonction
Doctorant.e
Identifiants
https://libra.unine.ch/handle/123456789/34953
_
0000-0002-6970-8862

Résultat de la recherche

Filtres

11
2
2
2
Réinitialiser les filtres

Paramètres

Voici les éléments 1 - 2 sur 2
  • Publication
    Accès libre
    Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus
    (2023)
    Sergio M. Latorre
    ;
    Vincent M. Were
    ;
    Andrew J. Foster
    ;
    Thorsten Langner
    ;
    Angus Malmgren
    ;
    Adeline Harant
    ;
    Soichiro Asuke
    ;
    Reyes Avila, Sarai 
    ;
    Dipali Rani Gupta
    ;
    Cassandra Jensen
    ;
    Weibin Ma
    ;
    Nur Uddin Mahmud
    ;
    Md. Shåbab Mehebub
    ;
    Rabson M. Mulenga
    ;
    Abu Naim Md. Muzahid
    ;
    Sanjoy Kumar Paul
    ;
    S. M. Fajle Rabby
    ;
    Abdullah Al Mahbub Rahat
    ;
    Lauren Ryder
    ;
    Ram-Krishna Shrestha
    ;
    Suwilanji Sichilima
    ;
    Darren M. Soanes
    ;
    Pawan Kumar Singh
    ;
    Alison R. Bentley
    ;
    Diane G. O. Saunders
    ;
    Yukio Tosa
    ;
    Croll, Daniel 
    ;
    Kurt H. Lamour
    ;
    Tofazzal Islam
    ;
    Batiseba Tembo
    ;
    Joe Win
    ;
    Nicholas J. Talbot
    ;
    Hernán A. Burbano
    ;
    Sophien Kamoun
    ;
    Joseph Heitman
    Wheat, one of the most important food crops, is threatened by a blast disease pandemic. Here, we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa following two independent introductions from South America. Through a combination of genome analyses and laboratory experiments, we show that the decade-old blast pandemic lineage can be controlled by the Rmg8 disease resistance gene and is sensitive to strobilurin fungicides. However, we also highlight the potential of the pandemic clone to evolve fungicide-insensitive variants and sexually recombine with African lineages. This underscores the urgent need for genomic surveillance to track and mitigate the spread of wheat blast outside of South America and to guide preemptive wheat breeding for blast resistance.
  • Publication
    Accès libre
    Histone H3K27 Methylation Perturbs Transcriptional Robustness and Underpins Dispensability of Highly Conserved Genes in Fungi
    (2021)
    Sabina Moser Tralamazza
    ;
    Abraham, Leen Nanchira 
    ;
    Reyes Avila, Sarai 
    ;
    Benedito Corrêa
    ;
    Croll, Daniel 
    ;
    Jeffrey Townsend
    AbstractEpigenetic modifications are key regulators of gene expression and underpin genome integrity. Yet, how epigenetic changes affect the evolution and transcriptional robustness of genes remains largely unknown. Here, we show how the repressive histone mark H3K27me3 underpins the trajectory of highly conserved genes in fungi. We first performed transcriptomic profiling on closely related species of the plant pathogen Fusarium graminearum species complex. We determined transcriptional responsiveness of genes across environmental conditions to determine expression robustness. To infer evolutionary conservation, we used a framework of 23 species across the Fusarium genus including three species covered with histone methylation data. Gene expression variation is negatively correlated with gene conservation confirming that highly conserved genes show higher expression robustness. In contrast, genes marked by H3K27me3 do not show such associations. Furthermore, highly conserved genes marked by H3K27me3 encode smaller proteins, exhibit weaker codon usage bias, higher levels of hydrophobicity, show lower intrinsically disordered regions, and are enriched for functions related to regulation and membrane transport. The evolutionary age of conserved genes with H3K27me3 histone marks falls typically within the origins of the Fusarium genus. We show that highly conserved genes marked by H3K27me3 are more likely to be dispensable for survival during host infection. Lastly, we show that conserved genes exposed to repressive H3K27me3 marks across distantly related Fusarium fungi are associated with transcriptional perturbation at the microevolutionary scale. In conclusion, we show how repressive histone marks are entangled in the evolutionary fate of highly conserved genes across evolutionary timescales.