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Boophiline, an Antimicrobial Sterol Amide from the Cattle Tick <i>Boophilus microplus</i>
Auteur(s)
Potterat, Olivier
Hostettmann, Kurt
Höltzel, Alexandra
Jung, Günther
Petrini, Orlando
Date de parution
1997
In
Helvetica Chimica Acta, Wiley, 1997/80/7/2066-2072
Résumé
Boophiline (<b>1</b>), a new sterol amide was isolated from the cattle tick <i>Boophilus microplus</i> (Ixodidae). The structure was assigned as N-[3-(sulfooxy)-25ξ-cholest-5-en-26-oyl]-L-isoleucine by detailed 2D NMR investigations in conjunction with FAB mass spectrometry and acidic hydrolyses. Complete assignment of the diastereotopic methylene protons of the ring system could be deduced from the NMR data. In agar dilution assays, <b>1</b> exhibited antifungal properties against <i>Cladosporium cucumerinum</i> and antibacterial activity against <i>Bacillus subtilis</i> and <i>Escherichia coli</i>.
Identifiants
Type de publication
journal article
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